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Repare Therapeutics Inc. (RPTX) SEC Filing 10-Q Quarterly Report for the period ending Wednesday, June 30, 2021

Repare Therapeutics Inc.

CIK: 1808158 Ticker: RPTX

Exhibit 99.1

 

 

Repare Therapeutics Provides Business Update and Reports First Quarter 2021 Financial Results

 

Introduced PKMYT1 as synthetic-lethal target for tumors with CCNE1 amplification or FBXW7 loss and highlighted program progress at RP-6306 Virtual Investor Day Event

 

Announced enrollment of first patient in RP-6306 Phase 1 clinical trial

 

Activated 10 clinical trial sites across North America and Europe for the PARP-inhibitor combination arm of the RP-3500 TRESR Phase 1/2 clinical trial

 

 

 

Cambridge, MA & Montreal, QC, May 13, 2021 (BUSINESS WIRE)

-- Repare Therapeutics Inc. (“Repare” or the “Company”) (Nasdaq: RPTX), a leading clinical-stage precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics, today reported financial results for the first quarter ended March 31, 2021.

 

“We have advanced the Phase 1/2 clinical development of our ATR inhibitor RP-3500, with initial results expected from the monotherapy arm of the trial in the second half of 2021. The PARP inhibitor and RP-3500 combination arm is now recruiting,” said Lloyd M. Segal, President and Chief Executive Officer of Repare. “We are pleased that the first patient has been dosed in our Phase 1 clinical trial of RP-6306, materially ahead of the timeline we disclosed at the time of our IPO last June.”

 

First Quarter 2021 Review and Operational Updates:

 

Highlighted program progress and introduced PKMYT1 as synthetic-lethal target to CCNE1 and FBXW7 at RP-6306 Virtual Investor Day Event.

 

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In April 2021, the Company highlighted pre-clinical anti-tumor activity of RP-6306, a potential first-in-class small molecule product candidate targeting PKMYT1, which is synthetic lethal with CCNE1 amplification, FBXW7 loss, and potentially other genomic alterations.

 

Announced enrollment of first patient in RP-6306 Phase 1 clinical trial.

 

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In April 2021, the Company dosed the first patient in its Phase 1 clinical trial of RP-6306.

 

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The trial (NCT04855656) is expected to enroll approximately 60 patients with recurrent tumors characterized by genomic alterations predicted by the Company’s SNIPRx® CRISPR-based platform to be sensitive to RP-6306.

 

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The trial objectives include assessment of safety, tolerability, dose and schedule (including the establishment of a recommended Phase 2 dose).


The following information was filed by Repare Therapeutics Inc. (RPTX) on Thursday, May 13, 2021 as an 8K 2.02 statement, which is an earnings press release pertaining to results of operations and financial condition. It may be helpful to assess the quality of management by comparing the information in the press release to the information in the accompanying 10-Q Quarterly Report statement of earnings and operation as management may choose to highlight particular information in the press release.

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Inside Repare Therapeutics Inc.'s 10-Q Quarterly Report:

Financial Statements, Disclosures and Schedules

Inside this 10-Q Quarterly Report

Document And Entity Information
Condensed Consolidated Balance Sheets (Parenthetical) (Unaudited)
Condensed Consolidated Balance Sheets (Unaudited)
Condensed Consolidated Statements Of Cash Flows (Unaudited)
Condensed Consolidated Statements Of Convertible Preferred Shares And Shareholders' Equity (Deficit) (Parenthetical) (Unaudited)
Condensed Consolidated Statements Of Convertible Preferred Shares And Shareholders' Equity (Deficit) (Unaudited)
Condensed Consolidated Statements Of Operations And Comprehensive Loss (Unaudited)
Accrued Expenses And Other Current Liabilities
Accrued Expenses And Other Current Liabilities (Tables)
Accrued Expenses And Other Current Liabilities - Schedule Of Accrued Expenses And Other Current Liabilities (Details)
Cash And Cash Equivalents And Marketable Securities
Cash And Cash Equivalents And Marketable Securities (Tables)
Cash And Cash Equivalents And Marketable Securities - Additional Information (Details)
Cash And Cash Equivalents And Marketable Securities - Summary Of Cash And Cash Equivalents And Marketable Securities (Details)
Collaboration And License Agreement
Collaboration And License Agreement (Tables)
Collaboration And License Agreement - Additional Information (Details)
Collaboration And License Agreement - Schedule Of Transaction Price Performance Obligations (Details)
Fair Value Measurements
Fair Value Measurements (Tables)
Fair Value Measurements - Additional Information (Details)
Fair Value Measurements - Schedule Of Financial Assets Measured At Fair Value On A Recurring Basis (Details)
Leases
Leases (Tables)
Leases - Additional Information (Details)
Leases - Summary Of Lease Costs (Details)
Leases - Summary Of Other Operating Lease Information (Details)
Net Loss Per Share
Net Loss Per Share (Tables)
Net Loss Per Share - Computation Of Diluted Net Loss Per Share In Attributable To Common Shareholders Indicate To Anti Diluted Effect (Details)
Net Loss Per Share - Summary Of Basic And Diluted Net Loss Per Share Attributable To Common Stockholders (Details)
Organization And Nature Of Business
Organization And Nature Of Business - Additional Information (Details)
Share-Based Compensation
Share-Based Compensation (Tables)
Share-Based Compensation - Additional Information (Details)
Share-Based Compensation - Schedule Of Fair Value Of Stock Options Determined On Grant Date Using Black Scholes Option-Pricing Model (Details)
Share-Based Compensation - Schedule Of Outstanding Stock Options (Details)
Share-Based Compensation - Schedule Of Share-Based Compensation Expense (Details)
Subsequent Events
Subsequent Events - Additional Information (Details)
Summary Of Significant Accounting Policies
Summary Of Significant Accounting Policies (Policies)
Ticker: RPTX
CIK: 1808158
Form Type: 10-Q Quarterly Report
Accession Number: 0001564590-21-043943
Submitted to the SEC: Thu Aug 12 2021 4:01:15 PM EST
Accepted by the SEC: Thu Aug 12 2021
Period: Wednesday, June 30, 2021
Industry: Pharmaceutical Preparations

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