Exhibit 99.1
(MEDICAL PROPERTY TRUST)
Contact: Charles Lambert
Finance Director
Medical Properties Trust, Inc.
(205) 397-8897
clambert@medicalpropertiestrust.com
MEDICAL PROPERTIES TRUST, INC. REPORTS
FOURTH QUARTER AND 2010 RESULTS
Total 2010 Investments of $213 Million, Exceeding Target by 42%;
Additional Acquisitions of $87.1 Million in January 2011
     Birmingham, AL — January 27, 2011 —
Medical Properties Trust, Inc. (NYSE: MPW) today announced financial and operating results for the quarter and year ended December 31, 2010.
FOURTH QUARTER AND RECENT HIGHLIGHTS
    Reported fourth quarter Normalized Funds from Operations (“FFO”) and Adjusted FFO (“AFFO”) per diluted share of $0.17 and $0.17, respectively, in-line with company guidance;
 
    Acquired two free standing long term acute care hospitals (LTACH) in December and expects to acquire a third property in the first quarter of 2011, for an aggregate of $83.4 million, all leased to and operated by RehabCare, the nation’s third largest operator of LTACHs;
 
    Acquired an acute care hospital in Gilbert, Arizona for $17.1 million on January 4, 2011;
 
    Agreed to purchase the real estate of Alvarado Hospital in San Diego for $70.0 million;
 
    Entered into agreements for two additional investments aggregating $56.0 million;
 
    Paid 2010 fourth quarter cash dividend of $0.20 per share on January 6, 2011.
     “Building on the momentum from the end of last year, 2011 is off to a terrific start with $87.1 million deployed in new investments in January alone and a strong near-term pipeline,” said Edward K. Aldag, Jr., Chairman, President and CEO of Medical Properties Trust, Inc. “When combined with the $213.0 million of new properties we announced in the second half of 2010, we have committed to more than $300 million in high quality new assets; twice the amount we previously estimated for acquisitions in 2010,” said Aldag. The weighted average initial cash lease rate for these investments is approximately 10.3%. Furthermore, Aldag stated that the Company presently expects to close by early February on an additional approximately $56.0 million of assets that are subject to binding agreements. There is no assurance that all or any of these transactions will be completed.

1


The following information was filed by Medical Properties Trust Inc (MPW) on Thursday, January 27, 2011 as an 8K 2.02 statement, which is an earnings press release pertaining to results of operations and financial condition. It may be helpful to assess the quality of management by comparing the information in the press release to the information in the accompanying 10-K Annual Report statement of earnings and operation as management may choose to highlight particular information in the press release.

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