(MKS LOGO)

EXHIBIT 99.1

Contact: Seth H. Bagshaw
Vice President, Chief Financial Officer & Treasurer
Telephone: 978.645.5578

MKS Instruments Reports Fourth Quarter and
Full Year 2011 Financial Results

Q4 Exceeds Guidance; Record Sales to Other Advanced Markets in 2011

Andover, Mass., February 1, 2012 — MKS Instruments, Inc. (NASDAQ: MKSI), a global provider of technologies that enable advanced processes and improve productivity, today reports fourth quarter and full year 2011 financial results.

Fourth Quarter Financial Results

Sales were $171.7 million, a decrease of 12% from $194.5 million in the third quarter of 2011, and a decrease of 22% from $219 million in the fourth quarter of 2010.

Fourth quarter net income was $22.7 million, or $0.43 per diluted share, compared to net income of $30.4 million, or $0.57 per diluted share in the third quarter of 2011, and $35.9 million, or $0.70 per diluted share in the fourth quarter of 2010.

Non-GAAP net earnings, which exclude special charges, were $20.4 million, or $0.38 per diluted share, compared to $30.6 million, or $0.58 per diluted share in the third quarter of 2011, and $34.4 million, or $0.67 per diluted share in the fourth quarter of 2010.

Full Year Results

Sales were $822.5 million, a decrease of 4% from $853.1 million in 2010. Net income was $129.7 million, or $2.45 per diluted share, compared to $142.6 million, or $2.80 per diluted share in 2010. Non-GAAP net earnings were $127.9 million, or $2.42 per diluted share, compared to $133.4 million, or $2.62 per diluted share in 2010.

Leo Berlinghieri, Chief Executive Officer and President, said, “2011 was another strong year for MKS. In the first half of the year we delivered our two strongest revenue quarters on record, and, even though we saw a slowdown in the second half, we continued to demonstrate the strength of our financial model and our ability to rapidly adjust to changing business conditions. While sales to our semiconductor customers declined 8% in 2011, we were pleased to set a new record for sales to other advanced markets, which grew to $321 million for the year. We added $140 million in net cash and investments to the balance sheet, declared quarterly dividends returning $31.4 million to our shareholders during 2011, and initiated a $200 million stock repurchase program. 2011 marked a major milestone, as we celebrated our 50th anniversary of serving our customers.

“Looking ahead, since last quarter, capital spending projections for 2012 have improved, and we saw our order rates improve shortly after our last call. We currently expect that sales in the first quarter of 2012 may range from $175 to $195 million, and at these volumes, our non-GAAP net earnings could range from $0.31 to $0.44 per share.”

Conference Call Details

A conference call with management will be held on Thursday, February 2, 2012 at 8:30 a.m. (Eastern Time). To participate in the conference call, please dial (877) 212-6076 for domestic callers and (707) 287-9331 for international callers, and an operator will connect you. Participants will need to provide the operator with the Conference ID of 40616915, which has been reserved for this call. A live and archived webcast of the call will be available on the company’s website at www.mksinst.com.

Use of Non-GAAP Financial Results

Non-GAAP net earnings and Non-GAAP net earnings per share amounts exclude discontinued operations, amortization of acquired intangible assets, costs associated with acquisitions and disposition related charges, and certain adjustments to income taxes. These non-GAAP measures are not in accordance with Accounting Principles Generally Accepted in the United States of America (GAAP). MKS’ management believes the presentation of these non-GAAP financial measures, which exclude discontinued operations and disposition related charges, amortization of acquired intangible assets, costs associated with acquisitions, the related tax effect of any adjustments and income tax adjustments related to settlement of tax audits, is useful to investors for comparing prior periods and analyzing ongoing business trends and operating results.

About MKS Instruments

MKS Instruments, Inc. is a global provider of instruments, subsystems and process control solutions that measure, control, power, monitor and analyze critical parameters of advanced manufacturing processes to improve process performance and productivity. Our products are derived from our core competencies in pressure measurement and control, materials delivery, gas composition analysis, control and information technology, power and reactive gas generation, and vacuum technology. Our primary served markets are manufacturers of capital equipment for semiconductor devices, and for other thin film applications including flat panel displays, solar cells, light emitting diodes, data storage media, and other advanced coatings. We also leverage our technology in other markets with advanced manufacturing applications including medical equipment, pharmaceutical manufacturing, energy generation, and environmental monitoring.

Forward-Looking Statements

This release contains projections or other forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, Section 27 of the Securities Act, and Section 21E of the Securities Exchange Act regarding MKS’ future growth and the future financial performance of MKS. These projections or statements are only predictions. Actual events or results may differ materially from those in the projections or other forward-looking statements set forth herein. Among the important factors that could cause actual events to differ materially from those in the projections or other forward-looking statements are the fluctuations in capital spending in the semiconductor industry, and other advanced manufacturing markets, fluctuations in net sales to MKS’ major customers, potential fluctuations in quarterly results, the challenges, risks and costs involved with integrating the operations of MKS and any acquired companies, dependence on new product development, rapid technological and market change, acquisition strategy, manufacturing and sourcing risks, volatility of stock price, international operations, financial risk management, and future growth subject to risks. Readers are referred to MKS’ filings with the Securities and Exchange Commission, including its most recent Annual Report on Form 10-K and Quarterly Reports on Form 10-Q, for a discussion of these and other important risk factors concerning MKS and its operations. MKS is under no obligation to, and expressly disclaims any obligation to, update or alter its forward-looking statements, whether as a result of new information, future events or otherwise.

###

1

MKS Instruments, Inc.
Unaudited Consolidated Statements of Operations
(In thousands, except per share data)

                         
    Three Months Ended (Note 1)
    December 31, 2011   December 31, 2010   September 30, 2011
Net revenues
  $ 171,671     $ 218,978     $ 194,508  
Cost of revenues
    95,710       121,657       106,830  
 
                       
Gross profit
    75,961       97,321       87,678  
Research and development
    14,224       15,790       14,331  
Selling, general and administrative
    31,473       32,880       31,984  
Amortization of intangible assets
    264       250       251  
 
                       
Income from operations
    30,000       48,401       41,112  
Interest income, net
    275       303       272  
 
                       
Income from continuing operations before income taxes
    30,275       48,704       41,384  
Provision for income taxes
    7,561       14,528       11,011  
 
                       
Income from continuing operations
    22,714       34,176       30,373  
Income from discontinued operations, net of taxes
          1,773        
 
                       
Net income
  $ 22,714     $ 35,949     $ 30,373  
 
                       
Basic income per share:
                       
Continuing operations
  $ 0.43     $ 0.68     $ 0.58  
Discontinued operations
          0.03        
 
                       
Net income
  $ 0.43     $ 0.71     $ 0.58  
Diluted income per share:
                       
Continuing operations
  $ 0.43     $ 0.67     $ 0.57  
Discontinued operations
          0.03        
 
                       
Net income
  $ 0.43     $ 0.70     $ 0.57  
Cash dividends per common share
  $ 0.15     $     $ 0.15  
Weighted average shares outstanding:
                       
Basic
    52,465       50,415       52,456  
Diluted
    53,105       51,245       52,992  
The following supplemental Non-GAAP earnings information is presented to aid in understanding MKS’ operating results:
                       
Income from continuing operations
  $ 22,714     $ 34,176     $ 30,373  
Adjustments (net of tax, if applicable):
                       
Settlement of foreign tax audit
    (2,548 )            
Amortization of acquired intangible assets
    264       250       251  
Proforma tax adjustments
    (71 )     (66 )     (67 )
 
                       
Non-GAAP net earnings (Note 2)
  $ 20,359     $ 34,360     $ 30,557  
 
                       
Non-GAAP net earnings per share (Note 2)
  $ 0.38     $ 0.67     $ 0.58  
 
                       
Weighted average shares outstanding
    53,105       51,245       52,992  

Note 1: During 2010, the Company sold two product lines that no longer met the Company’s long-term strategic objectives. The results of operations of the two product lines have been classified as discontinued operations in the consolidated statements of operations for the prior year period provided.

Note 2: The Non-GAAP net earnings and Non-GAAP net earnings per share amounts exclude results of discontinued operations and disposition related charges, amortization of acquired intangible assets, costs associated with acquisitions, the related tax effect of any adjustments and income tax adjustments related to settlement of tax audits.

2

MKS Instruments, Inc.
Unaudited Consolidated Statements of Operations
(In thousands, except per share data)

                 
    Twelve Months Ended December 31, (Note 1)
    2011   2010
Net revenues
  $ 822,517     $ 853,114  
Cost of revenues
    447,529       474,476  
 
               
Gross profit
    374,988       378,638  
Research and development
    61,033       62,689  
Selling, general and administrative
    128,015       119,841  
Amortization of intangible assets
    1,015       1,283  
Gain on sale of asset
          (682 )
 
               
Income from operations
    184,925       195,507  
Interest income, net
    1,127       917  
 
               
Income from continuing operations before income taxes
    186,052       196,424  
Provision for income taxes
    56,321       63,505  
 
               
Income from continuing operations
    129,731       132,919  
Income from discontinued operations, net of taxes
          9,668  
 
               
Net income
  $ 129,731     $ 142,587  
 
               
Basic income per share:
               
Continuing operations
  $ 2.49     $ 2.66  
Discontinued operations
          0.19  
 
               
Net income
  $ 2.49     $ 2.85  
Diluted income per share:
               
Continuing operations
  $ 2.45     $ 2.61  
Discontinued operations
          0.19  
 
               
Net income
  $ 2.45     $ 2.80  
Cash dividends per common share
  $ 0.60     $  
Weighted average shares outstanding:
               
Basic
    52,169       50,077  
Diluted
    52,847       50,927  
The following supplemental Non-GAAP earnings information is presented to aid in understanding MKS’ operating results:
               
Income from continuing operations
  $ 129,731     $ 132,919  
Adjustments (net of tax, if applicable):
               
Settlement of foreign tax audit
    (2,548 )      
Amortization of acquired intangible assets
    1,015       1,283  
Gain on sale of asset (Note 2)
          (682 )
Proforma tax adjustments
    (268 )     (113 )
 
               
Non-GAAP net earnings (Note 3)
  $ 127,930     $ 133,407  
 
               
Non-GAAP net earnings per share (Note 3)
  $ 2.42     $ 2.62  
 
               
Weighted average shares outstanding
    52,847       50,927  

Note 1: During 2010, the Company sold two product lines that no longer met the Company’s long-term strategic objectives. The results of operations of the two product lines have been classified as discontinued operations in the consolidated statements of operations for the prior year period provided.

Note 2: The twelve month period ended December 31, 2010 includes a $682 gain on the sale of a vacated facility.

Note 3: The Non-GAAP net earnings and Non-GAAP net earnings per share amounts exclude results of discontinued operations and disposition related charges, amortization of acquired intangible assets, costs associated with acquisitions, the related tax effect of any adjustments and income tax adjustments related to settlement of tax audits.

3

MKS Instruments, Inc.
Unaudited Consolidated Balance Sheet
(In thousands)

                 
    December 31, 2011   December 31, 2010
ASSETS
               
Cash and short-term investments
  $ 565,519     $ 431,933  
Trade accounts receivable, net
    120,894       138,181  
Inventories
    153,632       156,429  
Other current assets
    44,856       26,352  
 
               
Total current assets
    884,901       752,895  
Property, plant and equipment, net
    72,487       68,976  
Goodwill
    140,084       140,020  
Intangible assets, net
    1,043       1,743  
Long-term investments
    7,873        
Other assets
    12,266       18,779  
 
               
Total assets
  $ 1,118,654     $ 982,413  
 
               
LIABILITIES AND STOCKHOLDERS’ EQUITY
               
Short-term borrowings
  $ 1,932     $  
Accounts payable
    24,853       36,427  
Accrued expenses and other liabilities
    69,646       73,259  
 
               
Total current liabilities
    96,431       109,686  
Other liabilities
    32,211       25,688  
Stockholders’ equity:
               
Common stock
    113       113  
Additional paid-in capital
    707,419       663,792  
Retained earnings
    268,870       171,356  
Other stockholders’ equity
    13,610       11,778  
 
               
Total stockholders’ equity
    990,012       847,039  
 
               
Total liabilities and stockholders’ equity
  $ 1,118,654     $ 982,413  
 
               

4


The following information was filed by Mks Instruments Inc (MKSI) on Wednesday, February 1, 2012 as an 8K 2.02 statement, which is an earnings press release pertaining to results of operations and financial condition. It may be helpful to assess the quality of management by comparing the information in the press release to the information in the accompanying 10-K Annual Report statement of earnings and operation as management may choose to highlight particular information in the press release.

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