(MKS LOGO)

EXHIBIT 99.1

Contact: Ronald C. Weigner
Vice President of Finance & Treasurer
Telephone: 978.645.5576

MKS Instruments Reports Fourth Quarter and
Full Year 2009 Financial Results
Q4 Sales up 41% Sequentially

Andover, Mass., February 3, 2010 — MKS Instruments, Inc. (NASDAQ: MKSI), a global provider of technologies that enable advanced processes and improve productivity, reports fourth quarter and full year 2009 financial results.

Fourth Quarter Financial Results

Sales were $149.3 million, up 41 percent from $106.3 million in the third quarter of 2009 and up 19 percent from $125.2 million in the fourth quarter of 2008.

Fourth quarter net income was $14.9 million, or $0.30 per diluted share, compared to net losses of $4.0 million, or ($0.08) per basic share, in the third quarter of 2009 and $6.3 million, or ($0.13) per basic share, in the fourth quarter of 2008.

Non-GAAP net earnings, which exclude special charges, were $15.5 million, or $0.31 per diluted share, compared to $1.6 million, or $0.03 per diluted share, in the third quarter of 2009 and $0.1 million, or breakeven in the fourth quarter of 2008.

Full Year Results

Net sales were $411.4 million, down 36 percent compared to $647.0 million in 2008. The net loss was $212.7 million, or ($4.31) per basic share, compared to net income of $30.1 million, or $0.59 per diluted share, in 2008. Non-GAAP net loss was $2.6 million, or ($0.05) per basic share, compared to net earnings of $41.4 million, or $0.82 per diluted share in 2008.

Leo Berlinghieri, Chief Executive Officer and President, said, “In the fourth quarter we saw further acceleration in our core semiconductor business and we are seeing signs of improvement in the general market as well. Forecasters are predicting that the global economy is recovering and they are optimistic about a strong 2010.

“After enjoying a very positive uptick in sales in the past two quarters, we expect to see continued growth in the semiconductor market in 2010. We also expect that the improvement in the global economy, combined with our market diversification, will result in increased sales to our non semiconductor markets, fueling additional growth in 2010. Based on these factors and current customer activity, we anticipate that business in the first quarter of 2010 will continue to improve. We estimate that our first quarter sales may range from $170 to $190 million and at these volumes, our non-GAAP net earnings could range from $0.36 to $0.49 per share, and our GAAP net income could range from $0.35 to $0.48 per share.”

Management will discuss fourth quarter and full year financial results on a conference call tomorrow at 8:30 a.m. (Eastern Time). Dial-in numbers are 1-877-941-9205 for domestic callers and 1-480-629-9835 for international callers. The call will be broadcast live and available for replay at www.mksinstruments.com. To hear a telephone replay through February 11, 2010, dial 1-303-590-3030, access code 4203019#.

The financial results that exclude certain charges and special items are not in accordance with Accounting Principles Generally Accepted in the United States of America (GAAP). MKS’ management believes the presentation of non-GAAP financial measures, which exclude costs associated with acquisitions and special items, is useful to investors for comparing prior periods and analyzing ongoing business trends and operating results.

MKS Instruments, Inc. is a global provider of instruments, subsystems and process control solutions that measure, control, power, monitor and analyze critical parameters of advanced manufacturing processes to improve process performance and productivity. Our products are derived from our core competencies in pressure measurement and control, materials delivery, gas composition analysis, electrostatic charge management, control and information technology, power and reactive gas generation, and vacuum technology. Our primary served markets are manufacturers of capital equipment for semiconductor devices, and for other thin film applications including flat panel displays, solar cells, data storage media, and other advanced coatings. We also leverage our technology in other markets with advanced manufacturing applications including medical equipment, pharmaceutical manufacturing, energy generation, and environmental monitoring.

This release contains projections or other forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, Section 27 of the Securities Act, and Section 21E of the Securities Exchange Act regarding MKS’ future growth and the future financial performance of MKS. These projections or statements are only predictions. Actual events or results may differ materially from those in the projections or other forward-looking statements set forth herein. Among the important factors that could cause actual events to differ materially from those in the projections or other forward-looking statements are the fluctuations in capital spending in the semiconductor industry, fluctuations in net sales to MKS’ major customers, potential fluctuations in quarterly results, the challenges, risks and costs involved with integrating the operations of MKS and any acquired companies, dependence on new product development, rapid technological and market change, acquisition strategy, manufacturing and sourcing risks, volatility of stock price, international operations, financial risk management, and future growth subject to risks. Readers are referred to MKS’ filings with the Securities and Exchange Commission, including its most recent Annual Report on Form 10-K, for a discussion of these and other important risk factors concerning MKS and its operations. MKS is under no obligation to, and expressly disclaims any obligation to, update or alter its forward-looking statements, whether as a result of new information, future events or otherwise.

###

1

MKS Instruments, Inc.
Unaudited Consolidated Statements of Operations
(In thousands, except per share data)

                         
    Three Months Ended
    December 31, 2009   December 31, 2008   September 30, 2009
Net sales
  $ 149,270     $ 125,180     $ 106,262  
Cost of sales
    86,536       80,571       66,783  
 
                       
Gross profit
    62,734       44,609       39,479  
Research and development
    13,681       19,277       12,114  
Selling, general and administrative
    27,814       30,518       24,385  
Amortization of acquired intangible assets
    872       1,949       871  
Impairment of intangible assets
          6,069        
Restructuring
    (44 )           168  
 
                       
Income (loss) from operations
    20,411       (13,204 )     1,941  
Interest income, net
    156       1,287       263  
 
                       
Income (loss) before income taxes
    20,567       (11,917 )     2,204  
Provision (benefit) for income taxes
    5,620       (5,627 )     6,177  
 
                       
Net income (loss)
  $ 14,947     $ (6,290 )   $ (3,973 )
 
                       
Net income (loss) per share:
                       
Basic
  $ 0.30     $ (0.13 )   $ (0.08 )
Diluted
  $ 0.30     $ (0.13 )   $ (0.08 )
Weighted average shares outstanding:
                       
Basic
    49,509       48,712       49,461  
Diluted
    50,459       48,712       49,461  
The following supplemental Non-GAAP earnings information is presented to aid in understanding MKS’ operating results:
                       
GAAP net income (loss)
  $ 14,947     $ (6,290 )   $ (3,973 )
Adjustments (net of tax, if applicable):
                       
Amortization of acquired intangible assets
    872       1,949       871  
Excess & obsolete inventory adjustment
          5,000        
(Note 1)
                       
Restructuring and related items (Note 2)
    (44 )           168  
Impairment of intangible assets (Note 3)
          6,069        
Expense for income taxes (Note 4)
          (1,823 )      
Proforma tax adjustments
    (279 )     (4,855 )     4,497  
 
                       
Non-GAAP net earnings (Note 5)
  $ 15,496     $ 50     $ 1,563  
 
                       
Non-GAAP net earnings per share (Note 5)
  $ 0.31     $ 0.00     $ 0.03  
 
                       
Weighted average shares outstanding — diluted
    50,459       49,680       50,298  

Note 1: Cost of Sales for the three month period ended December 31, 2008 includes $5,000 of excessive E&O inventory charges.

Note 2: The three month periods ended December 31, 2009 and September 30, 2009 includes $(44) and $168, respectively, of restructuring charges (adjustments) primarily for severance related costs.

Note 3: The three month period ended December 31, 2008 includes a $6,069 write-down for the impairment of intangible assets resulting from a lower forecast for a product for the semiconductor industry.

Note 4: The three month period ended December 31, 2008 includes a benefit of $1,823 attributable to a discrete tax matter related to the reinstatement of the U.S. research and development tax credits and other adjustments.

Note 5: The Non-GAAP net earnings (loss) and Non-GAAP net earnings (loss) per share amounts exclude amortization of acquired intangible assets, acquisition and disposition related charges and special items, net of applicable income taxes.

2

MKS Instruments, Inc.
Unaudited Consolidated Statements of Operations
(In thousands, except per share data)

                 
    Twelve Months Ended December 31,
    2009   2008
Net sales
  $ 411,406     $ 646,994  
Cost of sales
    273,316       387,051  
 
               
Gross profit
    138,090       259,943  
Research and development
    53,543       78,540  
Selling, general and administrative
    106,330       130,800  
Amortization of acquired intangible assets
    4,407       9,001  
Goodwill and asset impairment charges
    208,497       6,069  
Restructuring
    5,812        
 
               
Income (loss) from operations
    (240,499 )     35,533  
Impairment of investments
          (906 )
Interest income, net
    1,641       6,425  
 
               
Income (loss) before income taxes
    (238,858 )     41,052  
Provision (benefit) for income taxes
    (26,199 )     10,935  
 
               
Net income (loss)
  $ (212,659 )   $ 30,117  
 
               
Net income (loss) per share:
               
Basic
  $ (4.31 )   $ 0.61  
Diluted
  $ (4.31 )   $ 0.59  
Weighted average shares outstanding:
               
Basic
    49,318       49,717  
Diluted
    49,318       50,754  
The following supplemental Non-GAAP earnings information is presented to aid in understanding MKS’ operating results:
               
GAAP net income (loss)
  $ (212,659 )   $ 30,117  
Adjustments (net of tax, if applicable):
               
Amortization of acquired intangible assets
    4,407       9,001  
Excess & obsolete inventory adjustment (Note 1)
    12,900       5,000  
Restructuring and related items (Note 2)
    4,514        
Goodwill and asset impairment charges (Note 3)
    208,497       6,069  
Foreign exchange gain from legal entity restructuring (Note 4)
          (2,669 )
Expense (benefit) for income taxes (Note 5)
    (6,370 )     400  
Proforma tax adjustments
    (13,897 )     (6,485 )
 
               
Non-GAAP net earnings (loss) (Note 6)
  $ (2,608 )   $ 41,433  
 
               
Non-GAAP net earnings (loss) per share (Note 6)
  $ (0.05 )   $ 0.82  
 
               
Weighted average shares outstanding — diluted
    49,318       50,754  

Note 1: Cost of Sales for the twelve month periods ended December 31, 2009 and December 31, 2008 includes $12,900 and $5,000, respectively, of special charges for excess, obsolete and committed inventory purchases.

Note 2: The twelve month period ended December 31, 2009 includes $5,812 of restructuring charges primarily for severance related costs offset by a credit of $1,298 for the reversal of previously expensed equity compensation charges of terminated employees.

Note 3: The twelve month periods ended December 31, 2009 and December 31, 2008 includes $208,497 and $6,069, respectively of charges related to the impairment of goodwill, intangible assets and other long-lived assets.

Note 4: Selling, general and administrative expenses for the twelve month period ended December 31, 2008 includes a foreign exchange gain of $2,669 related to the Company’s legal entity restructuring of certain foreign operations.

Note 5: The twelve month period ended December 31, 2009 includes a benefit of $6,370 attributable to the reversal of FIN 48 reserve items as a result of a Federal audit close. The twelve month period ended December 31, 2008 includes a net tax expense for discrete items of $400 attributable to the booking of a valuation allowance on tax attributes of $3,467 partially offset by a benefit of $3,067 for discrete items mainly related to the reversal of FIN 48 reserve items as a result of a statute of limitations expiration.

Note 6: The Non-GAAP net earnings (loss) and Non-GAAP net earnings (loss) per share amounts exclude amortization of acquired intangible assets, acquisition and disposition related charges and special items, net of applicable income taxes.

3

MKS Instruments, Inc.
Unaudited Consolidated Balance Sheet
(In thousands)

                 
    December 31, 2009   December 31, 2008
ASSETS
               
Cash and short-term investments
  $ 271,795     $ 278,869  
Trade accounts receivable
    94,215       85,350  
Inventories
    118,004       131,519  
Other current assets
    48,867       32,990  
 
               
Total current assets
    532,881       528,728  
Property, plant and equipment, net
    67,196       82,017  
Goodwill
    144,511       337,765  
Other acquired intangible assets
    4,963       21,069  
Other assets
    24,518       15,360  
 
               
Total assets
  $ 774,069     $ 984,939  
 
               
LIABILITIES AND STOCKHOLDERS’ EQUITY
               
Short-term debt
  $ 12,991     $ 18,678  
Accounts payable
    26,292       19,320  
Accrued expenses and other liabilities
    32,017       37,937  
 
               
Total current liabilities
    71,300       75,935  
Long-term debt
    18       396  
Other long-term liabilities
    17,818       21,910  
Stockholders’ equity:
               
Common stock
    113       113  
Additional paid-in capital
    645,411       637,938  
Retained earnings
    28,769       241,428  
Other stockholders’ equity
    10,640       7,219  
 
               
Total stockholders’ equity
    684,933       886,698  
 
               
Total liabilities and stockholders’ equity
  $ 774,069     $ 984,939  
 
               

4


The following information was filed by Mks Instruments Inc (MKSI) on Wednesday, February 3, 2010 as an 8K 2.02 statement, which is an earnings press release pertaining to results of operations and financial condition. It may be helpful to assess the quality of management by comparing the information in the press release to the information in the accompanying 10-K Annual Report statement of earnings and operation as management may choose to highlight particular information in the press release.

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